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Endocrine Abstracts

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ea0044p201 | Reproduction | SFEBES2016

Alterations of specific caveolin isoforms in the rat uterus under insulin resistance and hyperandrogenism conditions: does metformin contributes to their regulation?

Hu Min , Zhang Yuehui , Sun Xue , Sun Xiaoyan , Meng Fanci , Shao Ruijin , Billig Hakan

The caveolin (CAV) consists of three isoforms (CAV1, CAV2, and CAV3) and contributes to insulin-regulated glucose metabolism. It has been reported that decreased caveolin-1 phosphorylation in the endometrium is linked with insulin resistant state in women with polycystic ovary syndrome (PCOS). Because PCOS patients often display hyperandrogenism, whether hyperandrogenism in addition to insulin resistant is involved in the regulation of caveolin expression and activation in the...
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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